This document details the proposed statistical and health economic analyses for the QUIT hospital-based tobacco dependence treatment service.  The document is divided into sections that represent the main components of the analyses proposed.  This document represents the ‘core’ statistical and health economic analysis plan, which was developed with a focus on the acute inpatient setting to stimulate ongoing discussions which will inform the development of supplementary analysis plans for the other settings (i.e., specific considerations for specific settings, but following the core analyses detailed in this document).